Franklin D. Roosevelt Left an Indelible Mark on American...

â€Å"A whole generation of Americans had grown up knowing no other president. He was a presence in their living rooms, he had called them my friends, and he had been at the helm of the two worst crisis of the century.† (â€Å"FDR†) The people loved his optimism and his sympathy with the less fortunate. (Perkins, 7) He was the people’s champion and they elected him to office four consecutive times. (Schlesinger, Time) President Roosevelt rescued America during the hardship that was the great depression. His decision to enter World War II played a substantial role in defeating fascism. Roosevelt believed in a multilateral effort in ending conflicts around the world. Franklin D. Roosevelt left an indelible mark of progress on American history.†¦show more content†¦(Anonymous) Roosevelt had to fulfill his most important campaign promise, the new deal. â€Å"If the new deal is a success, a friend told Roosevelt in 1933, you will be remembered as the greate st American president. If I fail, Roosevelt replied, I will be remembered as the last one. â€Å" (â€Å"FDR†) Roosevelt moved to put the government itself on a budget, freeing up federal dollars for relief and reform measures. (www.pbs.org) He boosted the morale by making the sale of beer and wine legal. FDR also launched a congregation of recovery endeavors, which were dubbed â€Å"alphabet soup† programs for the acronyms that identified them. The civilian conservation Corps (CCC) put 2.5 million men to work on conservation and reforestation projects. (Stolley, 86) FDR believed that the assembling of the National Recovery Administration was the most important legislation of the early New Deal. â€Å"The NRA was meant to stop wasteful competition, encourage better regulated pricing and selling policies and provide for higher wages and shorter hours throughout the American business community.† (Alsop, 123) During the Farm crisis, President Roosevelt initiated the Agricultural Adjustment Act (AAA). This financed farmers for limiting the size of their crops. It assisted to make the farming community more solvent, also at the same time reducing the massive surpluses that had run down produce prices. (Alsop, 124) The most popular New Deal ideasShow MoreRelatedThe Policy Of Neutrality During World War II1555 Words   |  7 PagesOn September 5, at its outset, the United States declared and maintained its policy of neutrality in the Second World War. Following ongoing atrocities committed by the Axis powers, however, President Franklin D. Roosevelt felt compelled to limit their strength by freezing their U.S. assets and restricting trade of certain goods. Soon after the bombing of Pearl Harbor, Congress unanimously declared war on Japan. Days later, the rest of the Axis powers, including Nazi Germany, Italy, and their smallerRead MoreEudora Welty a Worn Path12166 Words   |  49 Pagesseeing an old African−American woman walking alone across the southern landscape. In A Worn Path, the womans trek is spurred by the need to obtain medicine for her ill grandson. Along the way, Phoenix encounters several obstacles and the story becomes a quest for her to overcome the trials she faces, which mirror her plight in society at large. The story is one of the best examples of Weltys writing, which is known A Worn Path 1 for its realistic portrayal of the American South, particularlyRead MoreEudora Welty a Worn Path12173 Words   |  49 Pagesseeing an old African−American woman walking alone across the southern landscape. In A Worn Path, the womans trek is spurred by the need to obtain medicine for her ill grandson. Along the way, Phoenix encounters several obstacles and the story becomes a quest for her to overcome the trials she faces, which mirror her plight in society at large. The story is one of the best examples of Weltys writing, which is known A Worn Path 1 for its realistic portrayal of the American South, particularly

Sir Gawain and the Green Knight Essay - 595 Words

Sir Gawain Part of the essence of drama is conflict. A man cannot be considered a hero unless he has overcome some form of opposition. In many cases, this opposition comes in the form of another character. Typically, the conflict is simplified as a malignant character with wicked intentions committing acts which would be characterized as evil; the protagonist opposes this villain and usually overcomes that character, winning the day and the admiration of all. Sometimes, the main character becomes a hero by overcoming some force within his or her own self. In Sir Gawain and the Green Knight, this is ultimately what Gawain must do in order to be considered a hero. Sir Gawain is originally faced with the challenge of the Green Knight.†¦show more content†¦That heroic character is frequently placed on a pedestal. From old folk tales to modern pop-culture, a hero is often seen as being generally respected and admired for his heroism. Throughout the course of his quest, Gawain must face temptation and the less-than-heroic qualities within himself-and he does not necessarily overcome them all. As Sir Gawain presses on in his search for the Green Chapel, he faces numerous physical challenges. Yet he overcomes them all to the point that to tell but the tenth part would tax my wits (1719) as he has countless battles with serpents, wolves, and the like. The true challenges come after he arrives at Bercilaks castle. There, he is tempted three times by Lady Bercilaks advances--yet he does not give in to her advances, nor spurn her completely in an uncourtly manner. Further, he does not accept her gift of the ring which she offers as a remembrance. However, when she offers her green girdle, proclaiming its properties of protection: Then the man began to muse, and mainly he thought It was a pearl for his plight, the peril to come When he gains the Green Chapel to get his reward: Could he escape unscathed, the scheme were noble! (1855-58) His greatest foe ultimately turns out to be not the Green Knight, but himself, as the major conflict is within: his own fear of death. He does triumph over that fear insofar as he seeks out the GreenShow MoreRelatedSir Gawain And The Green Knight1359 Words   |  6 PagesIn the poem â€Å"Sir Gawain and The Green Knight,† a protagonist emerges depicting an Arthurian knight named Sir Gawain. Sir Gawain, King Arthur’s nephew, takes initiative by accepting the challenge requested by the Green Knight in place of his uncle. He undergoes a perilous adventure, seeking for the Green Knight to receive the final blow. Although Sir Gawain is not viewed as a hero for his military accomplishments, he is, however, viewed as a heroic figure by the Knights at the Round Table for hisRead MoreSir Gawain And The Green Knight862 Words   |  4 PagesIn Sir Gawain and the Green Knight, by an unknown author referred to as the â€Å"Pearl Poet,† we are introduced to Sir Gawain. Gawai n is a knight of the Round Table and he is also the nephew of King Arthur. As a knight, Gawain is expected to possess and abide by many chivalrous facets. Throughout the poem he portrays many of the qualities a knight should possess, such as bravery, courtesy, and honor among others. Because of his ability to possess these virtues even when tempted to stray away from themRead MoreSir Gawain and the Green Knight1100 Words   |  5 PagesThe poem of Sir Gawain and the Green Knight compares a super natural creature to nature. The mystery of the poem is ironic to the anonymous author. The story dates back into the fourteenth century, but no one knows who originally wrote the poem. This unknown author explains in the poem of Sir Gawain not knowing of the location of the Green Chapel and or who the Green Knight really is. This keeps the reader entertained with the suspicion of not knowing. The author then does not give his name orRead MoreSir Gawain And The Green Knight Essay1687 Words   |  7 PagesSir Gawain and the Green Knight contains ambiguity and irony that make it interesting to read and teach. Gawain’s conflict arose when he accepted the girdle that could protect him and when he lied to his host, severing fellowship with the lord for courtesy with the lady. By utilizing a social reconstructionist philosophy of teaching that emphasizes personal beliefs and ethics, a teacher will help the students establish their identities and learn to appreciate classic literature. Sir Gawain and theRead MoreSir Gawain And The Green Knight1514 Words   |  7 PagesSir Gawain and the Green Knight is an epic poem written in the mid to late fourteenth century by an unknown author. Throughout the tale, Sir Gawain, a Knight at the Round Table in Camelot, is presented with many hardships, the first being a challenge on Christmas by a man in which, â€Å"Everything about him was an elegant green† (161). This â€Å"Green Knight† challenged someone in Came lot to accept his game which they will chop off his head with his axe and the Green Knight will do the same to the playerRead MoreSir Gawain And The Green Knight1335 Words   |  6 PagesSir Gawain: The Ironic Knight Sir Gawain and the Green Knight is a tale of the utmost irony in which Sir Gawain, the most loyal and courteous of all of King Arthur’s knights, fails utterly to be loyal and courteous to his king, his host, his vows, and his God. In each case, Sir Gawain not only fails to perform well, but performs particularly poorly, especially in the case of his relationship with God. Ultimately, Sir Gawain chooses magic over faith, and by doing so, shows his ironic nature as aRead MoreSir Gawain And The Green Knight906 Words   |  4 Pagesusually the latter. In Sir Gawain and the Green Knight we see Sir Bertilak go off to hunt three very specific animals as a game with Sir Gawain. They agree that â€Å"what ever [Bertilak catches] in the wood shall become [Sir Gawain’s], and what ever mishap comes [Sir Gawain’s] way will be given to [Bertilak] in exchange.† (Sir Gawain†¦, ln 1105-1007). In this deal we slowly see Gawain loose his honor as paralleled with Sir B ertilak’s hunt. The first animal that is hunted by the knight is a deer, while thisRead MoreSir Gawain And The Green Knight Essay1521 Words   |  7 PagesFall 16 Donnelly Many years ago, knights were expected to form a certain type of relationship with their king, this relationship was otherwise known as fealty. Fealty is a knight’s sworn loyalty to their king (in other words a loyal relationship should be formed between the two). The use of this relationship is shown in the poem called â€Å"Sir Gawain and the Green Knight† ( the author is unknown). This poem has a classic quest type of formula, with a knight receiving a challenge and then going outRead MoreSir Gawain And The Green Knight1455 Words   |  6 PagesHowever, for Gawain in Sir Gawain and the Green Knight temptation existed around every corner while he was playing the game of the Green Knight. Temptation existed every day and each day it existed in a new way. Gawain never knew what was coming his way throughout the grand scheme of the game, but one thing was for certain he was being tested. Without his reliance religious faith and dedication to his reputation, Gawain wo uld not have been able to make it through the game of the Green Knight alive andRead MoreSir Gawain And The Green Knight Essay1020 Words   |  5 PagesBoth Sir Gawain, from â€Å"Sir Gawain and the Green Knight† translated by Marie Borroff, and Beowulf, from Beowulf translated by Burton Raffel, serve as heroes in different times of Medieval English Literature. Many of the basic principles that describe heroes in Medieval Literature are seen in both of these characters even though they were written in different times. There are distinct similarities, differences, and also a progression of what the hero was in English literature, between Sir Gawain and

Accounting-People Oriented” Free Essays

Is the hotel service of the highest frequency words in one, but how to understand the â€Å"people-oriented†, and fell at the service Implementation, but not so simple. Four Seasons Hotel prior to the opening trial of business is not facing society, but to face the staff, commissioning a month, the staff try to eat a month, identify problems, stop at any time, In order to ensure the quality of the opening one hundred percent. This Is a people – the guests when the hotel can not be â€Å"Guiana pigs. We will write a custom essay sample on Accounting-People Oriented† or any similar topic only for you Order Now From this concept, the Four Seasons Hotel is no interns. Employees must be strengthened into the store a series of training to meet the requirements of posts, appointment is a formal work – services must be perfect for guests, not the internship process. A defect In the current hotel is the rooms, restaurants, PA, recreational and other first-line lack of understanding among the various departments, the hotel also provides that employees of various departments can not â€Å"string Kong,† and this will inevitably affect the overall service quality and team spirit. The last of a series of raining is to allow employees to do the day the guests, In addition to free room arrangements, and the other 600 distributed to staff, the staff wear casual consumption in the hotel, dining, fitness, the bar can be, requiring employees to stand in the guest point of the hotel experience, understanding customers. Proceeding to create a high degree of satisfaction with the service, and also from the beginning so that employees of various departments of the hotel have a comprehensive understanding facilitate future communication and coordination among departments. Four Seasons Hotel â€Å"people-oriented† high level of protection is n important embodiment of the guests right to privacy and equal respect for each guest. This Is, in our country, both conceptual Issues, but also the difficulty of the operation, while the Four seasons Hotel In respect of human rights Is the undying honor. – To the room, into the elevator key card to be plugged in, it stopped back in the appropriate floor. The hotel public areas without permission will be allowed to take pictures, because many people In public places, even seemingly private photos, but the background may still be related to other people, which have generated the aground of the possible infringement, which is strictly prohibited . If you really need camera can tell you specifically for the hotel arrangements. Each house guests are all equal, even if there is an important guests arrived, the hotel main entrance Is still to be set aside for dally guest channel and out of lanes and not al low sealed. If there is a conflict, the Four Seasons Hotel would rather not take the PIP guests have to absolutely guarantee the normal conditions of service. – Do not allow media access to the lobby guests take photos, such as: David Buckram’s â€Å"Posh† wife to Shanghai, the toll cordoned off at the door, the media must not go beyond. The more so, is the absolute guarantee that the store’s environmental quality, the guests privacy and freedom of movement. Media sometimes complained, but the principle unswervingly adhere to the Four Seasons Hotel. Personalized Four Seasons service quality is the bigger and more extreme, the cost of large, difficult to have the hotel can afford. SYNC TV united States President to Shanghai, the hotel Immediately contact professional organizations in Shanghai, the purchase of decoders, dedicated to the 1 OFF SYNC line II rooms Witt Conic’s channels Ana a Selene well-producer special programs; to the president of Pepsi-cola, the room All put on PepsiCo products; Philips president stayed, the rooms are full of Philips lighting replaced; Toast’s chairman, the head of the bed put a label marked with the model of Toyota cars; Samsung Electronics Company President of stay, hotel suites spared no expense to the other brands of high plasma TV removed and replaced by the latest models Samsung products. These benefits not only the boss, that is, a child, but also an equal footing. To store that also brought along a couple of old child, a child of the hotel immediately coupled with bathrobes, slippers and children, balloons and other small toys, extra bed is also consistent with the child’s height. It can be said, as long as visitor information, the Four Seasons Hotel are fully in place beforehand. Never use the hotel services, car floor, because the car, then most of the time during the day there are services out of the way the surface floor, guests have to sidle over, rude, tasteless, garbage bags on board the service, not elegant, another odor. At the same mime, there is baggage car floor, but there will be impact phenomena. Each floor of the hotel which had a small linen, the maintenance of daily turnover. Rooms at the Four Seasons hotel, only one printed on both sides â€Å"do not disturb† the morning of the plate, but not â€Å"come forward to clean† message. Shop CLC said that if there â€Å"dashing clean†, which means that the hotel’s commitment to the guests, it is not able to be kept. If the same floor a number of guests 10 rooms, while immediate cleaning is not feasible, and the guests is not to immediately clean up the worry level. Therefore, the hotel prompted guests, as long as the call to immediately clean up, immediately put in place, we must meet. The clean rooms and facilities engineering maintenance rooms must close the door, this is for hotel guests and staff security and privacy considerations. Close the door, the staff will hang outside the card – â€Å"We are cleaning your room. † Room table, covered with high-strength glass, in fact, everyone knows the problem, at home, in the office, all on the table, and the public use of the hotel room table, glass and India produce, and even cigarette butts, there ill be hot scorch , which gives the guests have the old sense of being damaged. Covered with glass, to resolve to the problem. Of course, under glass do not go into this kind of written material, a messy desktop, visual, taste is reduced. Of course, the name of such services, such as customers, it is essential. Floor attendant pocket has a piece of paper on which was written the name of this floor guests, guest name to see the greeting guests pay tribute to revered. The world has a different pronunciation of the language features, the hotel guests of different nationalities can best be understood. How to cite Accounting-People Oriented†, Essays

Strategy of An Organizational Changes †MyAssignmenthelp.com

Question: Discuss about the Strategy of An Organizational Change. Answer: The mentioned phrases are taken from the book, The Science of Successful Organizational Change by Paul Gibbons. In this book the author reflects his thought on the fact that scientific evidence is not important to prove everything. There are many books on organizational change that totally highlights the tactics and strategies of change but this book focused on the sound strategy of an organizational change which decreases the need for a broader tactical intervention of change. This book is categorized in three parts- change agility, change strategy and change tactics. A part of change leadership is also included (Gibbons, 2015). The range of change problem raises two questions in this book, one, what is the actual amount of change? Two, how much change is failed? Change depends on another important factor, i.e. leadership. So it can be derived that due to the lack of business education many leaders are not properly equipped with the factors which lead to change (Anderson, 2016). According to the authors, the capability to quickly create, learn, adapt and invent is an essential quality of this VUCA (volatility, uncertainty, complexity, ambiguity) world. It is not appropriate for every change to involve broken trust, external threat or unintentional consequences. In such a situation, the business suffers as a result of the fatigued, demoralized and unready major changes. Change agility gives rise to adaptive organizations, something that arises due to disruption in technologies and set a standard for the business as well as others to follow. Change strategy is looked onto when there is no tactical intervention to the defective strategy and that which leads to calculated changes in an organization. It can be said that change tactics is better than the change strategy because this portion looks after the contemporary human science for knowledge to lead the individuals towards change (Battilana Casciaro, 2012). In an article Organizational change and development, it is mentioned that organizational change is a very important factor in an organization. Through this process, an organization enhances the performance as it works and operates to attain the ideal goal, as mentioned by the author. The change takes place as a result of the changes taking place in the environment, as a response to the recent crisis situation or sometimes activated by the leader himself. An organizational change to be successful not only needs to be adjusted properly but also proper managing qualities. There are a number of factors which are taken into account for the organizational change to be successful. The article stated the reasons responsible for the changes in organization, the elements, process, approaches, management, resistance and other such criterion resulting in the breakdown. If it is looked from a passive point of view, the changes in an organization are just reactions to the constant change in the en vironment and the reaction of the recent crisis situation. In another way, a more energetic point of view is that it is sparked by an active manger. Moreover, changes in an organization are specifically noticeable when it has just gone through the shift of executive power (Beitler, 2013). It can be argued that as organization is a social system therefore all of its parts affect the other parts too. This is meant to say that the interconnection between the parts is so strong that the effect on one part gets transferred to other parts. But this connection is not just limited to the parts of the organization; it has spread to the surrounding environment also, the author mentioned. With the operation of the organization all the connections and relationships becomes stronger and that leads to the systematic and orderly behavior of the organization (Blackmore Sachs, 2012). It is said that the total system of the organization including the relationship among the parts is in an equilibrium state. It becomes a standard way of life and any disruption in this system of life exerts some force on the elements which have become adapted to that standard of life. It evolves a situation which might suggest an acceptance of the situation or less of interest in it or there might be pre ssure as opposed to the disruption. There are some situations in which the acceptance or ignorance of the disruption might not vary but the acceptance refers to cooperation while rejection refers to not being interested. Cameron and Green said that, the terminological meaning of change is the amendment that takes place in the total structure of an organization or the environment. It can be rightfully said that change is the law of nature. It is the only constant thing. It has some characteristics like - change takes place as a result of the force exerted both inside and outside an organization; there is an impact on the overall organization if there is any change in any part; change is a consistent factor and it can vary in speed and degree but it is sure to take place (Cameron Green, 2015). On the contrary, organizations that fail to bring about proper timely changes in an organization have a very bleak chance of survival. One cause of the rate of increase in change depends on the knowledge and technology, innovations being created at a constant and ascending rate. Change is not something that will disappear or vanish all of a sudden. The accelerating growth in change will take place due to the technology, recent applications and the spontaneity of creative ideas and thoughts. The mangers and their enterprises whether, service or manufacturing, private or public, will always be evaluated on their ability to bring about effective change in the organization and managing it efficiently (Choi, 2011). But the managers of the early 21st century, their ability to manage change were judged on the decrease in time scales. The speed at which changes take place has increased tremendously. Managers these days have to face more complicated and progressive working environments. Conve rgence has been taking place between the technologies and products as well as the industries that they support. Due to this convergence of services, products and industries, there is an increasing realization of comprehensive approach for the sales and marketing of products and services which will make the purchasing decisions easy. The challenges in strategy are designed to increase the value and at the same time, decrease the supply cost. These are in the run of becoming the most used elements for competition in the near future (Fugate, Prussia Kinicki, 2012). Command over the supply chain as well as its destruction will make good commercial activity in the competitive global market. Manufacturers nowadays not just make the products but distributes through proper network of dealers thus providing a good range of finance which can be related to different insurance packages. To argue over the fact it can be said that change refers to moving to an unknown state from the known, specifically from present to the future. Organizations just plan, experience and undergo change by thinking if the change forces can be adopted or dealt with. Happened change cannot be predicted from beforehand and arises due to the external factors (March, 2013). It leads to suffering as it is not in direct control but happens when the organization reach the extreme point of any situation. Incidents like deflation which can happen anytime and the organization has no control over it. Reactive change takes place completely as an after effect of any situation or an event. Most of the organizations are generally involved in reactive changes which can be incremental change. As it is explained by the authors, such changes take place when the company is in demand of products or services or a crisis situation arises. Anticipatory change takes place when there is an expectation or anticipat ion of any situation or an event. Sometimes organizations can reshape themselves according to the future demands to bring about an anticipatory change. A planned or developmental change takes place when there is a need to implement new ways for improvement (Engestrm Sannino, 2011). It is a measured change to achieve a fixed output. Incremental changes are adaptive in nature and directed at the primary level to focus on the smaller units of an organization. Operational changes take place when there is a need to improve the quality of products or services in the organization to cope up with the market competition (Schroeder, 2012). Strategic change refers to the change in an overall aspect of the organization including its strategies. Directional changes take place when there is high competition or change in the policy and procedures. Fundamental change refers to shaping of the mission and objective of the organization. Total change covers an overall amending of staff, vision, and pe rformance (Thomas, Hardy, 2011). The conclusion that can be drawn from this argumentative essay is that the most common factors of organizational change include strategy, vision, system, structure, culture, production technology and leadership style. These factors are very much influential for each other. The originality of vision is dependent on the implementation of perfect strategy for the organizations culture. So, the method in which the changes take place in an organization, if considered from a systematic point of view, different targets of change are considered in totality for attaining a successful organizational change. Organizational change explains creation of the imbalance in the already existing organizational pattern which tends to set up equilibrium in the environment. References Anderson, D. L. (2016).Organization development: The process of leading organizational change. Sage Publications. Battilana, J., Casciaro, T. (2012). Change agents, networks, and institutions: A contingency theory of organizational change.Academy of Management Journal,55(2), 381-398. Beitler, M. A. (2013).Strategic organizational change: a practitioner's guide for managers and consultants. Ppi. Benn, S., Dunphy, D., Griffiths, A. (2014).Organizational change for corporate sustainability. Routledge. Blackmore, J., Sachs, J. (2012).Performing and reforming leaders: Gender, educational restructuring, and organizational change. Suny Press. Brown, D. R., Harvey, D. F. (2011). An experiential approach to organization development. Burnes, B., Jackson, P. (2011). Success and failure in organizational change: An exploration of the role of values.Journal of Change Management,11(2), 133-162. Cameron, E., Green, M. (2015).Making sense of change management: A complete guide to the models, tools and techniques of organizational change. Kogan Page Publishers. Carter, M. Z., Armenakis, A. A., Feild, H. S., Mossholder, K. W. (2013). Transformational leadership, relationship quality, and employee performance during continuous incremental organizational change.Journal of Organizational Behavior,34(7), 942-958. Choi, M. (2011). Employees' attitudes toward organizational change: A literature review.Human Resource Management,50(4), 479-500. Choi, M., Ruona, W. E. (2011). Individual readiness for organizational change and its implications for human resource and organization development.Human Resource Development Review,10(1), 46-73. Engestrm, Y., Sannino, A. (2011). Discursive manifestations of contradictions in organizational change efforts: A methodological framework.Journal of Organizational Change Management,24(3), 368-387. Fugate, M., Prussia, G. E., Kinicki, A. J. (2012). Managing employee withdrawal during organizational change: The role of threat appraisal.Journal of Management,38(3), 890-914. Garcia, D., Gluesing, J. C. (2013). Qualitative research methods in international organizational change research.Journal of Organizational Change Management,26(2), 423-444. Gibbons, P. (2015).The Science of Successful Organizational Change: How Leaders Set Strategy, Change Behavior, and Create an Agile Culture. FT Press. Grant, D., Marshak, R. J. (2011). Toward a discourse-centered understanding of organizational change.The Journal of Applied Behavioral Science,47(2), 204-235. Greenberg, J. (2011).Behavior in organizations. Pearson. Hughes, M. (2011). Do 70 per cent of all organizational change initiatives really fail?.Journal of Change Management,11(4), 451-464. Jacobs, G., van Witteloostuijn, A., Christe-Zeyse, J. (2013). A theoretical framework of organizational change.Journal of Organizational Change Management,26(5), 772-792. Kossek, E. E., Hammer, L. B., Kelly, E. L., Moen, P. (2014). Designing work, family health organizational change initiatives.Organizational dynamics,43(1), 53. Lewis, L. (2011).Organizational change: Creating change through strategic communication(Vol. 4). John Wiley Sons. March, J. G. (Ed.). (2013).Handbook of Organizations (RLE: Organizations)(Vol. 20). Routledge. Oreg, S., Vakola, M., Armenakis, A. (2011). Change recipients reactions to organizational change: A 60-year review of quantitative studies.The Journal of Applied Behavioral Science,47(4), 461-524. Peirson, L., Ciliska, D., Dobbins, M., Mowat, D. (2012). Building capacity for evidence informed decision making in public health: a case study of organizational change.BMC Public Health,12(1), 137. Schroeder, C. (2012).Coming in from the margins: Faculty developments emerging organizational development role in institutional change. Stylus Publishing, LLC. Shin, J., Taylor, M. S., Seo, M. G. (2012). Resources for change: The relationships of organizational inducements and psychological resilience to employees' attitudes and behaviors toward organizational change.Academy of Management Journal,55(3), 727-748. Swanson, C. R., Territo, L., Taylor, R. W. (2016).Police administration: Structures, processes, and behavior. Prentice Hall. Thomas, R., Hardy, C. (2011). Reframing resistance to organizational change.Scandinavian Journal of Management,27(3), 322-331. Thomas, R., Sargent, L. D., Hardy, C. (2011). Managing organizational change: Negotiating meaning and power-resistance relations.Organization Science,22(1), 22-41. Volkoff, O., Strong, D. M. (2013). Critical Realism and Affordances: Theorizing IT-associated Organizational Change Processes.Mis Quarterly,37(3).

AP and Hills Like White Elephants

The choice of a narrative mode shapes the way in which readers perceive the actions of the main characters. This paper will include an analysis of two short stories, namely Hills Like White Elephants by Ernest Hemingway and AP by John Updike. These literary works exemplify different story-telling techniques which enable the writers to achieve various goals. Overall, it is possible to say that these authors are able to choose an approach that best fits their purposes. This is the main point that should be discussed more closely.Advertising We will write a custom essay sample on AP and Hills Like White Elephants specifically for you for only $16.05 $11/page Learn More First, it should be mentioned that these writers use different story-telling techniques. In particular, Updike relies on the first-person narration. The readers are prompted to look through the eyes of a teenage clerk, Sammy, who works at an AP supermarket. The main advantage of this approach is that the writer can throw light on the inner world of this character. For instance, this story-teller seems to be a cynical person. At first glance, one can say that he despises other people who he regards as slaves. Nevertheless, it is possible to argue that this first impression is very delusive. For instance, the narrative indicates that the protagonist desperately wants to produce a favorable impression on the girls who enter the AP store. Moreover, it becomes evident that Sammy is a romantic or even naà ¯ve individual. One can say that the first-person narration helps the writer to illustrate the conflicting motives that drive the behavior of the protagonist. Additionally, this character represents a wide group of young people who chose to rebel against the consumer culture. In his turn, Ernest Hemingway takes a different approach to story-telling. He relies on the third-person objective narration which means that the writer does not speak about the thoughts, emotions, or attitudes of the character. To a great extent, readers are prompted to reach their own conclusions about the plot and characters. Hills Like White Elephants can be viewed as a good example of this technique. In this case, the text of the short-story is mostly a dialogue between the two characters. The author does not try to evaluation the actions or arguments made by the protagonists. Additionally, the readers can only make conjectures about the subject which the characters discuss. For instance, one can suppose that the man tries to persuade the girl to undergo some form of surgery, probably abortion. However, one cannot say it for sure. The main detail is that Hemingway refuses to make any comments about the relations between these characters. This use of third-person objective narration enables the writer to intrigue the readers and arrest their attention. The main advantage of this method is that it helps the writer to pose thought-provoking questions to the audience. For exampl e, one can reflect on the future relations between the two characters. This is why the use of the third-person objective narration is quite justified.Advertising Looking for essay on american literature? Let's see if we can help you! Get your first paper with 15% OFF Learn More Thus, these examples show how different narrative modes can be applied. In particular, John Updike’s use of the first-person narration is critical for describing the inner world of an adolescent who cannot adjust to the consumer culture. In turn, Ernest Hemingway’s approach is critical for engaging the readers who are prompted to think about the motives that underlie the words or actions of the main characters. These are the main issues that can be identified. This essay on AP and Hills Like White Elephants was written and submitted by user Braylin Michael to help you with your own studies. You are free to use it for research and reference purposes in order to write your own paper; however, you must cite it accordingly. You can donate your paper here.

The History of Candy Canes

The History of Candy Canes Almost everyone alive grew up familiar with the hard red-and-white candy with the curved end known as a candy cane, but few people realize just how long this popular treat has been in existence. Believe it or not, the origin of the candy cane actually goes back hundreds of years to a time when candy-makers, both professional and amateur, were making hard sugar sticks as a favorite confection. It was around the beginning of the 17th century that Christians in Europe began to adopt the use of Christmas trees as part of their Christmas celebrations. The  trees were often decorated using foods such as cookies and sometimes sugar-stick candies. The original Christmas tree candy was a straight stick and completely white in color. Cane Shape The first historical reference to the familiar cane shape though goes back to 1670. The choirmaster at the Cologne Cathedral in Germany first bent the sugar-sticks into the shape of canes to represent a shepherds staff. The all-white candy canes were then given out to children during the long-winded nativity services. The clergymens custom of handing out candy canes during Christmas services would eventually spread throughout Europe and later to America. At the time, the canes were still white, but sometimes the candy-makers would add sugar-roses to further decorate the canes. In, 1847, the first historical reference to the candy cane in America appeared when a German immigrant named August Imgard decorated the Christmas tree in his Wooster, Ohio home with candy canes. Stripes About 50 years later, the first red-and-white-striped candy canes appeared. No one knows who exactly invented the stripes, but  based on historical Christmas cards, we know that no striped candy canes appeared prior to the year 1900. Illustrations of striped candy canes didnt even show up until the beginning of the 20th century. Around that time, candy-makers began adding peppermint and wintergreen flavors to their candy canes and those flavors would soon become accepted as the traditional favorites. In 1919, a candymaker named Bob McCormack began making candy canes.  And by the middle of the century, his company, Bobs Candies, became widely famous for their candy canes. Initially, the  canes  had to bent by hand to make the J shape. That changed with the help of his brother-in-law, Gregory Keller, who invented  a machine  to automate candy cane production. Legends and Myths There are many  other legends and religious beliefs surrounding the humble candy cane. Many of them depict the candy cane as a secret symbol for Christianity during a time when Christians were living under more oppressive circumstances. It has been claimed that the cane was shaped like a J for Jesus and that the red-and-white stripes represented Christs blood and purity. The three red stripes were also said to symbolize the Holy Trinity and the hardness of the candy represented the Churchs foundation on solid rock. As for the candy canes peppermint flavor, it represented the use of hyssop, an herb referred to in the Old Testament. However, no historical evidence exists to support these claims, although some will find them pleasant to contemplate. As noted earlier, candy canes werent even around until the 17th century, which makes some of these claims improbable.

Contrasting Codified Constitutions Case Study Example | Topics and Well Written Essays - 1500 words

Contrasting Codified Constitutions - Case Study Example The second part of the discussion relates to the amendments and the procedures related to the amendments of the two constitutions. Certain specific aspects of these constitutions as well as the safeguards incorporated or even the different forms of knowledge that could be use to interpret constitutional principles including the social and legal aspects are the main focus of this essay (Bogdanor and Rudden, 1995). The first part thus discusses main constitutional principles and separation of powers in the country in its constitutional forms. The second part of the essay discusses the amendments of a constitution and the different procedures for amending the constitutions of the two countries chosen. 2. The State shall secure that the operation of the legal system promotes justice, on a basis of equal opportunity, and shall, in particular, provide free legal aid, by suitable legislation or schemes or in any other way, to ensure that opportunities for securing justice are not denied to any citizen by reason of economic or other disabilities. (Constitution of India, 2007) In the matter of separating the judiciary from the executive, the Constitution states that -'The State shall take steps to separate the judiciary from the executive in the public services of the State'. b. ... (Constitution of India, 2007) In the matter of separating the judiciary from the executive, the Constitution states that -'The State shall take steps to separate the judiciary from the executive in the public services of the State'. In this context the roles and structure of the Executive could be given. The Executive consists of the President of India and the Vice President. The constitution states that - a. There shall be a President of India. b. The executive power of the Union shall be vested in the President and shall be exercised by him either directly or through officers sub-ordinate to him in accordance with this Constitution.(Constitution of India, retrieved 2007) The extent of the Executive Power of the Union is given by the following clauses - Extent of executive power of the Union.- (1) Subject to the provisions of this Constitution, the executive power of the Union shall extend- (a) to the matters with respect to which Parliament has power to make laws; and (b) to the exercise of such rights, authority and jurisdiction as are exercisable by the Government of India by virtue of any treaty or agreement: Provided that the executive power referred to in sub-clause (a) shall not, save as expressly provided in this Constitution or in any law made by Parliament, extend in any State to matters with respect to which the Legislature of the State has also power to make laws. (2) Until otherwise provided by Parliament, a State and any officer or authority of a State may, notwithstanding anything in this article, continue to exercise in matters with respect to which Parliament has power to make laws for that State such executive power or functions as the State or officer or authority thereof could exercise immediately before

Millstream Hotel and Restaurant Article Example | Topics and Well Written Essays - 1500 words

Millstream Hotel and Restaurant - Article Example The elegant sitting room, with its comfortable and luxurious, grand piano, sprinkled with freshly cut flowers and peaceful ambiance, is the ideal place to chat up with friends over afternoon tea or an aperitif. Bosham is an ideal center from which to discover this area of spectacular natural beauty and historical interest.   This beautiful hotel has 35 rooms out of which three are suites and each room is decorated in a uniquely elegant fashion with all the necessary amenities for a luxurious and comfortable stay. The hotel is located close to some good recreational facilities like golf, sailing, squash, riding and water sports which can be easily accessed. The popular restaurant is open all through the year and serves some of the most excellent delicacies in that part of town. There are a few famous historical attractions for the holidaymakers like Chichester Festival Theatre, Fishbourne Roman Palace, and West Dean Gardens. On a sunny day, the lawns can be inviting where you can relax under the shade and enjoy the ducks in the nearby lake. You can enjoy a pleasant evening in the beautiful and well-kept gardens along with your friends and family over a cup of tea and delicious snacks. A well maintained and luxurious spa can add a lot of value to the residents who can relax and enjoy a good massage or get pampered in style. The spa is the latest trend in the hotel industry around the world. You can add on a spa facility or take on a branded spa on the franchise which can boost your hotels' facility outlook to a great extent. Most of the clients now expect a spa in the hotel as they look for a complete relaxation package when checking into a hotel. The wellness tourism has caught on in a big way where health and wellness spas are frequented by tourists who are becoming health and beauty conscious. A well-equipped spa can provide guests with Jacuzzi, steam, sauna, exotic massages and various other treatments that would add on to the luxury of the hotel.  

Reserch proposal Dissertation Example | Topics and Well Written Essays - 2750 words

Reserch proposal - Dissertation Example Recently Saudi airlines have been criticized to be losing its customers due to their inferior customer service quality and poor price strategy. Customer is the heart and soul of any business organization, and if they are not pleased with the service or end product, then the business is doomed to failure. Any business needs to be revolving around the key concepts of customer satisfaction and customer loyalty. If customers are satisfied about a product or service, they keep coming back for more and also can attracts more customers from the potential market. Big airline companies like Saudi airlines, need to keep monitoring their quality of service in order to be top in the airline industry. They should make best use of the CRM programs to enhance their customer relation as well as profitability. According to (Avidian Technologies,2004) â€Å"Good CRM allows all of the information obtained to be shared among both the sales force and the entire company. The right CRM software should com bine all the elements of Customer Relationship Management, Sales Force Automation (SFA), and Contact Management†. Research Context I)Aim and Objective of the study The aim of this research is to assess the importance of the quality of service in improving customer service and loyalty in an airline service company. ... 2) To identify the research questions needed to be put forward in order to establish the research study. 3) Prepare a research design and data collection method. Specifically the questions which will be put forward in the research proposal will be as follows. 1. To what extend is the customers of Saudi Airlines satisfied with the customer service delivered by them? 2. Are the customers of the Saudi Airlines at the risk of leaving the airline? II) Relationship of service quality with customer satisfaction and loyalty Customer satisfaction is a very important criterion in any airline service, as this is the factor which helps in building the loyalty and the goodwill for the company. An unsatisfied customer is the root cause for the degradation of any service based industry. A good customer service is not just about profitability, but it is about how much value a business gives to its customer needs and requirements. Customer service definitely has to have access to the customer marketi ng database. Saudi Airlines being a top listed airline did not give much attention on the needs of the customer but took them for granted. It is seen that many complaints occur from customer as to flight delays, low service from cabin crew, inferior seating arrangements and poor welcoming services A customer is paying for a quality travel and if the airline is not considering on the quality of service, then they will lose the current customers as well as the potential future ones too. They have to know what each customer has bought in the past, and what they would expect in future. They have to have a record of past complaints and compliments. Customer is the soul of a business firm, and if they are treated well, then

Steps in the Process of Fertilization

Steps in the Process of Fertilization Fertilization is an essential process in sexual reproduction which involves the union of two specialized cells called the gametes to form a zygote. This then develops to form the new organism. During the process of fertilization innumerable number of sperms hit the surface of the eggs. But only one sperm succeeds in fertilizing it and the rest are repelled from the surface of the egg. This is done by the modification of cell envelope extracellular matrix besides altering the metabolic activity of the zygote or embryo. Various metabolic changes occur after the zygote is formed. This includes the respiratory burst hydrogen peroxide production activation of oxidases peroxidase alterations in the redox status changes in the activity of redox-sensitive transcription factors etc. Besides these an embryo-derived paf (1-o-alkyl-2-acetyl-sn-gylcero-3-phosphocholine) is synthesized and its release involves the binding to extracellular albumin which protects its enzymatic degradation (ONeill C , 1985). The change in the redox state affects the activity of redox-sensitive transcription factors that may alter gene expression patterns. Besides, this change in the metabolic status also, is responsible for the spatial differences in cell activity especially after compaction and major embryonic events such as fertilization genome activation and cellular differentiation (AJ Harvey et al, 2002). Multiple variations that occurs during this stage are found throughout phylogeny (Wessel G.M.et al., 2001; Shapiro B.M. et al, 1989). Three discrete steps are involved with the formation of extracellular barrier during the post-fertilisation stage (i.e. after zygote formation): Following cortical granule exocytosis an autoactivating serine protease separates plasma membrane attachments to the eggs vitelline layer facilitating the separation of this matrix from the egg surface (Haley S.A. and Wessel G.M., 1999). The structural components of the fertilization envelope (FE) primarily derived from the cortical granules (Wessel G.M. et al, 2001) self assemble into the vitelline layer network and form a distinct pattern of cytoskeleton like structures. (Chandler D.E. Heuser J. 1980). The cortical granule-derived enzyme ovoperoxidase is targeted to the FE by the tethering protein proteoliaisin (Somers C.E. et al, 1989). The structural proteins self-polymerise into fibers. This is followed by an increase in the ovoperoxidase activity in response to alkalization (Deits T.L. and Shapiro B.M., 1986) and an increase in the synthesis of hydrogen peroxide (Foerder C.A. et al 1978; Heinecke J.W. Shapiro B.M., 1989). Studies on nutrient uptake during fertilization have been done in various species(Leese Barton, 1984, Leese, 1991, Rieger, 1992, Rieger et al., 1992, Rieger Loskutoff, 1994, Gardner, 1999, Gopichandran Leese, 2003). However uptake of O2 is the major parameter that provides the required indication of overall metabolic status of a single zygote (Leese, 2003) as the production of ATP by oxidative phosphorylation a reaction in which O2 plays a major role (Thompson et al., 1996 Thompson, 2000 Leese, 2003). Furthermore the respiratory rates of single embryos is directly in correlation with quality (Abe Hoshi, 2003) and with survival following its transfer (Overstrà ¶m, 1992). When the production of the harmful reacting species eg., destructive oxygen species supersedes the bodys handling capacity through antioxidants, cellular damage occurs. This type of damage is the usual reason for most of the pathological states in animals, especially in nearly half of the infertile men. ROS bring their damage through various routes; the membrane of the sperm is damaged, which causes the motility rate of sperm to reduce and subsequently its inability to fuse with the egg during the fertilization process. ROS also alter the DNA of the sperm, leading to the improper genetic material getting transferred to the next generation. In spite of this, there is an inverse correlelation between the spermsa ability to produce ROS and their maturation. In the middle of the process of spermatogenesis, the cytoplasm of the sperm is lost due to its compaction (condensation) which is required for the elongation of sperm. This is witness from the study that immature teratozoospermic spe rms are featured by the presence of increased residues in cytoplasm in the mid-piece. Besides the cytotoxic damage caused by the levels of ROS in spermatozoa, hazardous oxygen metabolites produced by the leucocytes present in the ejaculate also damages it. This damage is more significant in the assisted conception therapy, where the contamination of the sperms washed, is presumed to the predominant factor determining the success rate of the fertilization, invitro. The so called reactive oxygen species ROS viz. H2O2 O2- · OH · etc affect the gametes and early reproductive events. ROS, produced by the peroxidation of the lipids, affects and changes the mitochondrial metabolism, besides producing more ROS. ROS are mainly known for their deleterious effects on spermatozoa and hence on male infertility (de Lamirande E et al, 1997, Sharma, RK Agarwal A, 1996, Shen, H Ong, C, 2000). Increased production of ROS has been associated with defects in the morphology of sperm (Aziz N et al 2004) inhibition of sperm motility (Armstrong JS et al, 1999, Parinaud J et al, 1997) fragmentation of sperm DNA (Donnelly ET et al, 1999) and premature capacitation (Villegas J et al, 2003). Further ROS also decreases the capacity for sperm-oocyte fusion efficiency and greatly inhibit the in vitro development of the embryo (Johnson MH et al, 1994, Guerin P et al, 2001, Mammoto A et al, 1996). More than six decades ago, it was discovered that the oxygen radicals (ROS) may have involved in the reproduction of human, especially men. (MacLeod, 1943). But the same was not studied to that extent in the case of female reproductive function, with only little works on pathological and physiological processes. Paszkowski observed that the selenium dependent glutathione peroxidase (SeGPx) was decreased in follicular fluids of women with no record of infertility (Paszkowski et al., 1995; Paszowski and Clarke, 1996). He also demonstrated that the levels of SeGPx were higher in those follicles which yielded oocytes that were successfully fertilized, compared to those follicles which yielded oocytes that failed to fertilize. Increased levels of hydrogen peroxide was found in the unfertilized oocytes also in fragmented embryos ( Yang et al., 1998). Whereas an increase in the antioxidant consumption was reported by Paszkowski and Clarke (1996) revealing an increase in the ROS activity, w hen poor quality embryos were incubated. Attaran et al (2000) observed a beneficial role of ROS, with its levels were high in the follicular fluid in IVF conception cycles compared to that of non-conception. Besides acting on sperm or oocytes separately, ROS were also reported to have its deleterious effect on sperm-oocyte fusion also. Studies reporting the fact the decrease in the levels of enzymes like catalase resulting in the loss of sperm motility. Many other studies produced a conclusive evidence for the production of ROS by human spermatozoa and showed that there was indeed an increase in the activity of ROS, in infertile men. If conventional method of invitro fertilization procedures were employed, even the spermatozoa whose DNA is damaged due to ROS, was able to fertilize the oocytes. Velocity measurements in the sperm motility studied under the impact of the ROS (generated by incubation with hydrogen peroxide) showed that the quality of sperm movement was significantly aff ected, but were motile, extremely; only the percentage motility was affected. Increased reactive oxygen species production was observed at 7 h and then at 24 h after IVF just before the first cleavage of the embryo. Increased oxidative activity and redox changes at the time of fertilization have been suggested to signal Ca2+ flux after the penetration of sperm. H2O2 besides being the substrate for ovoperoxidase is produced by a calcium-depending mechanism involving the reduction of one molecule of oxygen and the oxidation of two proton donors. Contrarily low levels of ROS has a positive effect on sperm functions (Bilodeau JF et al, 2000, de Lamirande E et al, 2003) binding of sperm to zona pellucida (Aitken RJ et al, 1989) and the development of embryo in bovine and other mammals (Harvey AJ et al, 2002 Guo Y et al, 2004, Harvey AJ et al, 2004). The concentration of ROS in both intracellular and extracellular are carefully regulated by enzymatic and nonenzymatic mechanisms and also by the presence of a detailed antioxidant defense mechanism in bovine oviductal tissues and fluids (Lapointe J et al 2003). Antioxidant genes especially a few glutathione peroxidases like GPx-1 Gpx-2 and Gpx-3 were differentially expressed along the oviduct. The major enzymes that are capable of metabolizing hydrogen peroxide (H2O2) belong to the family of GPx as well as the oviductal-catalase (Lapointe S et al, 1998, Brigelius-Flohe R, 1999). The concentration of oxygen that has to be utilized during the culture of embryos, influences the development and quality of the embryos. When the concentration of oxygen was reduced in the culture of mouse embryos, it altered the embryonic gene expression during the post-compaction stage. This has severe consequences on the fetal development of the mouse. (Deanne Feil, 2006). Furthermore blastocysts cultured under decreased O2 tension correlate more closely with in-vivo-recovered blastocysts than in vitro blastocysts cultured under normal O2 tension (Dumoulin JCet al, 1999; Yuan YQ et al, 2003; Johnson MH et al, 1994; Guerin P et al, 2001). The driving force for changes in the metabolic status of the zygote is the secretion of the cortical granules at least in sea urchins. The sea urchin embryo generates large amounts of H2O2 at the beginning of development of zygote and its levels are meticulously regulated to prevent any possible toxic effect. Because of this the sea urchin system provides greater insights into the control of reactive oxidants in biological systems. ROS can either positively or negatively affect the reproductive events in vitro. In the fertilization process the oviducts are the site of important processes that occur prior to implantation such as the maturation of oocyte in the initial stages of embryonic development (Harvey AJ et al 2002). They regulate the ROS levels to provide a proper environment for the gametes followed by their fertilization and the subsequent stages in the development of embryo. Vitamin E protects against the loss of the motility of the sperm through the peroxidation of lipids. Hence, supplementation of the same improved the motility of the sperm and enhanced the possibility of fertilization in asthenospermic invidicuals, even when the original sperm motility measured was only 20%. Spermatozoa exposed to PUFA showed an increase in its oxidative stress (Aitken, RJ, 2006). In particular, the oxidation of DHA- docosahexaenoic acid bound to phospholipid was shown to be one of the predominant factors that controls the mobility of the sperm in vitro. There is a marked cell to cell differences in the life span of sperm samples, which reflects in their susceptibility to lipid peroxidation. It is a well established fact that when a spermatozoa is subjected to oxidative stress, its membrane and the DNA is damaged through the membrane lipid peroxidation. The probability of this type of damaged spermatozoa will be able to fertilise the egg depends on the rate at which the functions of the sperm is lost. Till date, the research evidence shows that the motility of the sperm, its capacity to enter into acrosome reaction, its ability to integrate with vitelline membrane of the oocytes are all is prone to get affected by the oxidative stress. Of all the ROS, it is the superoxide anion and hydrogen peroxide that causes the deleterious damage to sperm capacitation and hence are the key mediators. The former contributes to the hyperactivated motility of the sperm, while the later is found to be associated with the tyrosine phosphorylation events in sperm capacitation. Current research have shown that the spermatozoa that are subjected to extreme oxidative stress using the method d escribed by Aitken RJ etal (1998) i.e, exposure to hydrogen peroxide and NADPH, have the capacity to reach the normal rate of fertilization with ICSI (intracytoplasmic sperm injection). The original postulate of the free radical hypothesis was that the ROS led to non specific modification of various biomolecules, such as proteins, lipids and nucleic acids. This is responsible for the etiology of the pathological condition that arises after that. The existence of oxidase activity was first documented while measuring oxygen consumption following fertilization (Warburg O., 1908). The increase in the oxygen consumption upon fertilization of sea urchin eggs is cyanide insensitive and produces H2O2 as the substrate for ovoperoxidase which crosslink the protective FE (Foerder C.A. et al, 1978). The assembly of ovoperoxidase into the fertilization envelope and the cross linking reaction are carefully regulated events that take place in ten minutes following gamete fusion (Weidman P.J. et al 1985). High oxygen concentrations are deleterious to early mammalian embryonic development (Thompson JG et al., 1990). Heinecke Shapiro have characterized an oxidase from unfertilized Stronglylocentrolus purpuratus eggs and had demonstrated its role as respiratory burst oxidase of fertilization. Their oxidase appears to be regulated by a protein kinase. It produces H2O2 when stimulated with Ca2+ and ATP and utilizes NADPH but not NADH as a source of reducing equivalents (Jay.W.Heinecke Bennett M. Shapiro, 1989; Li J Foote RH., 1993; Dumoulin JC et al., 1999). Some of the transcription factors including PEBP2 AP-1 p53 and NF-ÃŽÂ ºB are known to be regulated by the changes in the redox status and this regulation has been shown to occur through conserved cysteine residues in the DNA-binding regions of these proteins (Hirota K et al, 1997; Hirota K et al, 1999; Ueno M et al., 1999; Akamatsu Y et al., 1997). Role of à Ã¢â‚¬ °-3 fatty acids in fertilization Fatty acids are classified as: saturated monounsaturated and polyunsaturated (PUFA). There are two main classes of PUFA: n-3 (omega-3) and n-6 (omega-6); distinguished by the location of the first double bond i,e.,from the three or six carbon from the CH3 (methyl) end of the fatty acid. à Ã¢â‚¬ °-3 fatty acids are polyunsaturated fatty acids. Examples include ÃŽÂ ±-linolenic acid (ALA) eicosapentaenoic acid(EPA) and docosahexaenoic acid (DHA). The n-3 PUFAs are generated from ALA, found mostly in the chloroplasts of green plants and grass. These essential fatty acids can be converted to longer chain PUFAs, in liver, by desaturation and elongation enzymes, that is common to both. Fatty acid desaturase 2 (FADS2) is rate limiting (Gurr MI et al, 2002). The human cannot synthesize this, because they do not possess the required fatty acid desaturase enzymes and therefore have to be supplemented through diet. When the gene expression of this FADS2 enzyme is deleted the first step in the PUFA biosynthesis is stopped. This lack of PUFAs and eicosanoids did not interefere with viability or lifespan of female and male fads2-l mice, but resulted in sterility. Wilhelm S. etal (2008) demonstrated that phospholipids substituted with PUFA have a significant role in Sertolic cell polarity and blood-testis barrier, besides the gap junction network between the ovarian follicles granulose cells. They are implicated in various process in human, including reproduction, vision, neural development and growth (Gurr MI et al, 2002). For over a long period, these FAs have been implicated in the different stages of vertebrate fertilization. Either of n-6 or n-3 or both influence the reproductive processes through a heterogenous mechanisms, ranging from the providing the precursors for prostaglandin synthesis, steroid hormone biosynthesis, regulating the transcription factors involved. In ruminants, the pregnancy is established through the ovulation of the eligible oocytes, insemination at the right time and an adequate dosage of estradion and progesterone, during the luteal and follicular stages of the estrous cycle. Oocytes of cattle, when exposed to methyl palmoxirate to prevent the FA oxidation displayed low level of capcity to form blastocysts after fertilization. Moreover, the embryo have to develop completely to prevent luteolysis, which may occur by the interfereons production to inhibit up-regulation of the endometrial oxytocin receptors. Polyunsaturated fatty acids are also reported to modulate the function of the certain transcription factors that controls the gene expression and thus have a effect on the IC concentrations of the enzymes involved in the regulation of PG and steroid hormones synthesis. In bovine endometrial stromal cells and in lutenised granulose cells, both the omega-3 and 6 PUFAs are found to activate the protein kinase C, which activa tes the phosphodiesterase by phosphorylation. All these processes are affected by the dietary supplementationof PUFAs. Therefore changes in the PUFA sources subsequently reflects in the omega-3 and omega-6 content of the sperm. And these PUFAs are more susceptible to attack by the ROS as reported by various researchers. A schematic diagram showing a proposed mechanism in which the PUFAs generating the oxidative stress in human spermatozoa. High levels of poly unsaturated fatty acids in the spermatozoa of infertile human triggers the production of the ROS from a non mitochondrial source, (may be throughthe NADPH oxidase, NOX 5, influenzed by the calcium). Increased reactive oxygen species, ROS, then induces the peroxidation of lipids, which in turn shoots out the phospholipase A2, culminating in the release of more polysaturated fatty acids with subsequent generation of more ROS to perpetuate the oxidative stress. Dietary supplementation of n-3 PUFAs influence various aspects of fertility starting from conception and throughout the duration of pregnancy. (ESHRE Capri Workshop Group, 2006, Kind KL, et al, 2006). These n-3 PUFAs are incorporated in the phospholipids of the cell membrane and have their effects on membrane composition function, (Hong MY, 2002), ROS production (Hong MY, 2002 ,Watkins SM, 1998), membrane lipid peroxidation (Hawkins RA etal, 1998), regulators of transcription translation (Narayana BA et al 2001, Davidson LA2004), production of eicosanoids (Chapkins RS, 1991) and IC signal transduction (Ma D, 2004). Lupton JR (2004) had observed that these mentioned actions facilitate the n-3 PUFA-induced suppression of colon cancer. Similarly, alterations in the PG synthesis (mediated through the manipulation of the n-3 PUFAs) has profound effect on fertility, since PGs affect many aspects of fertilization, e.g., ovulation). Dietary supplementation of varying PUFA content to female cattle and to other mammals have found to alter the size and the number of ovarian follicles, the ovulation rate, the production of progesterone hormone by corpus luteum, the length of gestation and luteolysis timings. In male mammals, dietary PUFAs has demonstrated effect on sperm membrane PL composition and on the ability to fertilize (Abayasekara Wathes, 1999). For instance, sheep fed with diets containing high PUFAs delayed parturition (Baguma-Nibasheka et al. 1999). They also increased the incidence of placenta getting retained in cattle (Barnouin Chassagne 1991). High supplementation of ALA in diet, during the post partum period improved pregnancy rate in cattle (Kassa et al. 2002). Embryonic mortality was reduced through the suppression of uterine synthesis of prostaglandin F2alpha in cattle was brought about by altering the FA profile in their diets. This strategy of altering the FA profile in the diets, may be used to improve animal productivity by integrating the nutrit ion and reproductive management (Mattos R etal 2000). The fatty acid composition of both oocytes and sperm are responsible for the various observations in the study of the fertilization process in animals. The FA composition of the oocytes is specific for a given species both in terms of their abundance and their utilization. Among them, EPA, DHA and ARA have been associated in several stages of reproduction (Wathes DC etal 2007). Mature zebrafish oocytes fortify with ARA, indicating their capacity to synthesize eicosanoids for ovulation and follicular maturation. ARA along with LA was the most predominant PUFAs in oocytes of pig, sheep and cattle. (McEvoy etal 2000). Decreased ARA:EPA ratio in eggs and ovaries of fish have been reported as the reason for poor productivity in the captive broodstock (Pickova J, 2007, Cejas JR et al 2003). DHA along with EPA inhibited the gonadotrophin-mediated steroid hormone synthesis in cold and warm water fishes. These two highly unsaturated fatty acids (HUFA) act as regulator molecules in the maturat ion of those fish ovary (Mercure F et al 1995). Kim et al (2001) had observed that the quality of oocytes was influenced by the dietary FAs which changes the composition of granulose cells and oocytes. Based on those quality, the oocytes were divided in to grade1, 2, 3 etc. Kim also observed that there were differences in the FA composition between those grades of sheeps oocytes, which affected the oocytes competence, resulting in alterations in fertilization rate and developmental potential. Sheep fed with PUFAs had altered FA composition in their membrane PLs of cumulus cells, resulting in the alteration of the oocytes membrane properties (Zeron et al., 2002). Supplementation of n-6 and n-3 showed different reponses in reproduction (Wonnacot KE et al, 2010). Ewes fed with n-3 PUFAs prior to ovarian stimulation and follicular aspiration showed no changes in the follicle number and size. But follicular-fluid levels of progesterone were found to be greater and all the blastocycts (both treated and untreated with the stipulated diet ) contained increased levels of PUFAs, mostly ALA. Moreover, dietary supplementation of conjugated linoleic acid (CLA) to early-lactation dairy cows showed an improvement in their reproductive performance (MJ de Veth 2009). Cows fed with 18:3 FAs rich diets had a prolonged preovulatory follicle at insemination and larger volume of corpus luteum compared to those fed with MUFAs (Bilby TR, 2006). The deficiency of essential fatty acids affects the energy and fat metabolism, biosynthesis of PUFA, structure of cell membrane and signaling pathways in lipid resulting in incompatible life (Cunnane, 2003). Studies on fads2-/- mouse model had thrown light on the various effects of the deficiency of PUFAs, invididually,( ie, omega-3, omega-6 etc) and combined. In that study, FADS2 deficiency caused hypogonadism and sterility of male (azoospermia) female mice. Spermatogenesis is stopped in male fads2-/- mice occurred at the stage of round spermatids, leading to azoospermia. This is often caused by a damaged blood testis barrier BTB. BTB is formed by TJ and AJ protein complexes that are restricted to basolateral compartment of the more polarized sertoli cells (Fanning et al, 1998; Chapin et al, 2001; Ebnet et al, 2003). Similarly Thangavelu G etal (2007) have shown that the development of embryo was increased in Holstein cows that are fed with unsaturated fatty acids compared to those with saturated fatty acids. This shows that a diet rich in ÃŽÂ ±-linoleic acid facilitates the development of embryo when compared to that of linoleic or saturated fatty acids. Another observation which showed that, enriching the semen diluents with DHAs containing egg yolk prior to freezing did not enhance the sperm quality following thawing. In both human and in domestic animals, levels of the breakdown products of lipid peroxidation, such as malondialdehyde and 4-OHalkenal, had no correlation with the semen quality. But, studies on chickens showed that dietary supplementation with more PUFAs, decreased the antioxidant status and semen quality (i.e, sperm concentration and volume). In this context, the significance of the role of the non-enzymic antioxidant, vitamin-E (a chain breaking antioxidant), which reverses the negative effects caused by the PUFA supplementation is to be noted. Besides all the sources that had been mentioned in this introduction, the final source of oxidative stress is the sperm itself. Defective human sperms produce ROS, which is directly proportional to the extent of the impairment of the sperm function (Deluliis 2006). Another reason for sperm being a source for ROS is that some authors believe that they contain more amounts of unsaturated fatty acids, mainly DHA and AA (Ollero M, 2000). Their study demonstrated that exposing the human spermatozoa to various PUFAs resulted in the accelerated production of free radicals, subsequent to peroxidation of lipids and DNA damage. There is an abnormal retention of remnants of cytoplasm and a presence of increased levels of unsaturated fatty acids in the immature or defective human spermatozoa, which generated high levels of reactive oxygen species. PLA2 gets activated due to this peroxidation of lipid, which enhances the production of more free poly unsaturated fatty acid from the phospholipid fu rther increasing the production of ROS. In this situation, the fertilizing potential of spermatozoa under increased oxidative stress with concomitant low antioxidant status and more ROs production, will decrease dramatically as observed various researchers and in various species. Dietary n-3 PUFA affects reproductive processes including ovulation oocyte development and sperm levels motility. The in vivo morphology of oocytes is improved through a high supplementation of n-3 PUFA (zeron Y, 2002). PUFAs stimulate the generation of in vitro ROS (Aitken RJ et al 2006). In males the fatty acid composition of the sperm membrane influences their fertility and fertile men have much higher sperm levels of omega-3 FAs as compared to infertile men. Infertility and premature birth are two womens health issues where omega-3 levels are implicated. omega-3 supplementation decreased the clotting in the endometrial cells of the uterus and improved the implantation rates of fertilized eggs. Lower concentrations of spermatozoon DHA in asthenozoospermic men are not due to diet but to some type of metabolic difference (Conquer JA). Fouladi et al (2010) have shown that the ovary regulates the effects of alterations in plasma n-3 and n-6 FAs, resulting in only small effects on th eir developmental potential. The cessation of growth and some health problems in growing rats fed with low PUFAs were reversed after feeding the same with high PUFA sources rich in 18:3 ALA (Burr and Burr 1930). Reproduction in cattle is influenced more by the type of fats (ie. PUFA or MUFA) than with just fats as it is, reveals the importance of PUFAs in reproductive processes. This is more highlighted because ruminants extensively hydrogenate PUFAs, thereby limiting their supply for absorption in small intestine. Eicosanoids-independent mechanisms such as modulation of intracellular signaling pathways transcription factor activity and altered gene expression (Das UN., 2000; Dentin R et al, 2005; Simopoulos AP. et al, 2002). Fatty acids in the oocytes are utilized during its maturation and are incorporated into its cytoplasm (Ferguson EM et al, 2006; Kim JY et al, 2001). Changes in the n-3 PUFA levels in the diet alter the fatty acid composition of the oocytes and its surrounding environment affecting the oocytes maturation; modulate the development of follicles, ovulation, embryo development and developmental competence such as its ability to involve in fertilization. The changes in the diet profile for the n-3 PUFAs also had altered mitochondrial properties and increased the ROS levels in oocytes, suggesting a role for mitochondria in the impaired embryo development. Sarah et al (2008) studied the effect of diet supplementation of n-3 PUFA on the zygotes. Exposing the reproductive tract for a period of 22h (post hCG) found to increase the number of zygotes which are morphologically poor, especially when females were given a diet rich in n-3 PUFA. The in vivo-derived zygotes (which were morphologically normal) which were subjected to n-3 PUFA treatment failed to cleave and their development was delayed (Sarah et al, 2008). This was due to the impaired mitochondrial metabolism. Low and high levels of omega-3 concentrations in the blood have been implicated in various conditions. Hong et al. (2002) have observed n-3 FAs increase apoptosis in colonocytes when coincubated with butyrate. Eicosopentanoicacid increases oxidative stress leading to lipid peroxidation in Walker 256 rat tumor cells besides decreasing the mitochondrial membrane potential (Colquhoun A et al 2001.). in oocytes this change in mitochondrial membrane potential is observed to be a consequence of metabolic inhibitors (Van Blerkom J et al 2003) and have been correlated with developmental arrest in mouse two-cell embryo increased fragmentation (Acton BM et al 2004) and the rate of embryo development in the human (Wilding M et al 2001). Low omega-3 FA in blood leads to increase in menstrual pain. Lipids of the Oocyte are crucial for the energy requirement of the preimplantation zygote. They also participate in fertilization and in the subsequent cell differentiation (Amri et al., 1994). Oocytes that are oxidatively damaged have a low levels of PUFA and are unable to undergo fertilization (TarÄ ±Ãƒâ€šÃ‚ ´n et al., 1996). The levels of arachidonic acid and docosahexaenoic acid as well as lipid peroxidation in blood and seminal plasma of normozoospermic males from infertile couples compared with that of fertile volunteers indicate that systemic oxidative stress resulting in increased lipid peroxidation and an alteration in the fatty acid profile which may be responsible for infertility in men (Oborna I et al, 2009). The omega-6 or -3 fatty acids are the precursors for various metabolites produced in sperm and ovum which are necessary for fertilization. The precursors from omega-3 are less potent in generating ROS than omega-6. Therefore the gametes will be less affected by the effects of ROS under this condition. An imbalance in the omega-6-to-omega-3 ratio has been linked to various complications; like polycystic ovarian syndrome PCOS low sperm count etc. Treatment of cumulus-oocyte complexes (COCs) with ALA significantly increased the percentage of oocytes at the metaphase II an increase in the percentage of cleaved embryos the blastocyst rate and better -quality embryo compared with untreated controls while higher doses of it were detrimental (Waleed F et al, 2009). Thus the omega-3 FAs and the Redox regulators have multifarious roles before during and after the fertilization process. The role of the polyunsaturated fatty acids is important in both the physiology of sperm and ovum. This is highlighted by their key role in the maintaining the fluidity of the membrane of the sperm, which is needed for fertilization. Further, they are also a important part of the specific class of fucosylated slycosphigolipids, which are important for the male fertility. Besides these, they are also sources of alkoxyl and peroxyl radicals, to help these cells in the event of damages arising due to oxidative stress.

The Genealogy of Jesus Christ Essay -- New Testament, Matthew 1:2-17

The New Testament includes four Gospels that encompass a variety of narrative accounts relating to Jesus Christ. The Gospel of Matthew; is sequentially placed as the first book within the New Testament. Furthermore, it is a canonical account of the life of Jesus, and is recognized as one of the synoptic Gospels. These accounts are divided into twenty eight chapters that appear in the form of a parable, proverb, law, or miracle story found within modern day poetry, letters, or literary tracts. Moreover, each narrative account possesses influential and intellectual material that attracts readers to examine it further. However, out of the four Gospels, Matthew’s is the one that encompasses the most amount of text that bestows an array of narrative accounts of Jesus to observe. In Matthew’s scriptures he takes Jesus’ fulfillments of the Jewish prophecies into consideration and uses it to refute the Jewish belief that Jesus of Nazareth is not the Messiah. This paper will explore the pericope found in Matthew 1:2-17 that illustrates the genealogy of Jesus Christ. The purpose of the passage is to demonstrate that Jesus is indeed the Messiah, which is a dominant theme throughout this particular Gospel. The above passage was chosen to obtain a greater perspective on the genealogy of Jesus Christ, through further examining Matthew’s tactic of incorporating Jesus into various Jewish traditions and prophecies. This passage is particularly interesting because Matthew functions as a bridge between the two Testaments, by showing how prophetic â€Å"fulfillment citations† from the Hebrew Bible were fulfilled, in the person of Jesus therefore proving he is the Messiah .The book of Matthew is a complicated Gospel; as a result, it is vital for its ... ...s view Jesus as the Messiah and continue to worship him as the foundation of Christianity. As a result, it is evident that Christianity and Judaism possess different beliefs. Perhaps over time the two faiths will fuse together and allow the people to become unified and share the same beliefs towards the true Messiah. Bibliography Batten Alicia, Introduction to the New Testament. Sudbury: University of Sudbury, 2011. David S.Ariel â€Å"The Messiah† from What Do Jews Believe. New York: Schocken Books, 1996. Coogan, Michael D. The New Oxford Annotated Bible. New York: Oxford, 2007. Filson ,V. Floyd The Gospel According to St. Matthew. London: A. and C. Black Limited, 1960. Keener, Craig S. A Commentary on the Gospel of Matthew. Grand Rapids, MI: W.B. Eerdmans Pub., 1999. Print. Saldarini, Anthony Commentary On The Bible. Michigan: Wm. B. Eerdmans: 2003. The Genealogy of Jesus Christ Essay -- New Testament, Matthew 1:2-17 The New Testament includes four Gospels that encompass a variety of narrative accounts relating to Jesus Christ. The Gospel of Matthew; is sequentially placed as the first book within the New Testament. Furthermore, it is a canonical account of the life of Jesus, and is recognized as one of the synoptic Gospels. These accounts are divided into twenty eight chapters that appear in the form of a parable, proverb, law, or miracle story found within modern day poetry, letters, or literary tracts. Moreover, each narrative account possesses influential and intellectual material that attracts readers to examine it further. However, out of the four Gospels, Matthew’s is the one that encompasses the most amount of text that bestows an array of narrative accounts of Jesus to observe. In Matthew’s scriptures he takes Jesus’ fulfillments of the Jewish prophecies into consideration and uses it to refute the Jewish belief that Jesus of Nazareth is not the Messiah. This paper will explore the pericope found in Matthew 1:2-17 that illustrates the genealogy of Jesus Christ. The purpose of the passage is to demonstrate that Jesus is indeed the Messiah, which is a dominant theme throughout this particular Gospel. The above passage was chosen to obtain a greater perspective on the genealogy of Jesus Christ, through further examining Matthew’s tactic of incorporating Jesus into various Jewish traditions and prophecies. This passage is particularly interesting because Matthew functions as a bridge between the two Testaments, by showing how prophetic â€Å"fulfillment citations† from the Hebrew Bible were fulfilled, in the person of Jesus therefore proving he is the Messiah .The book of Matthew is a complicated Gospel; as a result, it is vital for its ... ...s view Jesus as the Messiah and continue to worship him as the foundation of Christianity. As a result, it is evident that Christianity and Judaism possess different beliefs. Perhaps over time the two faiths will fuse together and allow the people to become unified and share the same beliefs towards the true Messiah. Bibliography Batten Alicia, Introduction to the New Testament. Sudbury: University of Sudbury, 2011. David S.Ariel â€Å"The Messiah† from What Do Jews Believe. New York: Schocken Books, 1996. Coogan, Michael D. The New Oxford Annotated Bible. New York: Oxford, 2007. Filson ,V. Floyd The Gospel According to St. Matthew. London: A. and C. Black Limited, 1960. Keener, Craig S. A Commentary on the Gospel of Matthew. Grand Rapids, MI: W.B. Eerdmans Pub., 1999. Print. Saldarini, Anthony Commentary On The Bible. Michigan: Wm. B. Eerdmans: 2003.

Supply Chain and Risk Management

Introduction Like economies and financial markets, as supply chains grow more global and interconnected, they get more exposed to disruptions and risks. Moreover, the supply chain speed exacerbates the problem. Even minor miscalculations can have major consequences as the impact spreads like viruses throughout the complex supply chain networks. Hence, it is vital to build smarter supply chains and address the issues that pose a challenge to this objective. These risk factors can effect productivity, economy and band image of the company so it is very important to identify and manage these problems on right time. Risk is a set of unexpected or unpredictable event that directly or indirectly affects the efficient working of an organization. † So to avoid this situation there should be a effective risk management process which can help the company to work efficiently and effectively Risk management can be defined as Risk management is an important function in business industry. It is an entrepreneurial need which caters all the solution which are needed for the efficient working of an organization to achieve is goals. It helps the management to understand the root cause of the problem and all possible ways by which it can be solved.Risk management process About The Company Cipla is one of the pioneer’s in the Indian Pharmaceutical Industry. The company was first started in 1935 and throughout its long journey of 75years has introduced many life-changing and innovative drugs to serve humanity while supporting, improving and enriching millions of lives worldwide. Cipla has 50 manufacturing plants with its headquarters situated in Mumbai, India. Its current stable has over 1200 products in current production which can cure almost every illness known to man.Cipla boasts the world’s largest range of respiratory medicines, dosage forms and devices for the management of asthma and other respiratory illnesses. The company is well known for providing co nsistently high quality of medical updates and patient education material to help patients as well as doctors in their respective environments. The company had also setup a dedicated center which carried on research and education on respiration named the Chest Research Foundation (CRF) in Pune, India. The company has also pioneered revolutionary medicines for treatment of cancer, AIDS, hepatitis A, B and C. ardiovascular disease, arthritis, diabetes, weight control, depression and many other health conditions, distributing its product to almost every country. Recently the company had researched and created a medicine called QVIR that can cure AIDS and can be used for both first and second line treatment of HIV-AIDS. Currently, 40% of the worlds HIV patients undergoing anti AIDS therapy are taking Cipla Drugs. Pain Points with QVIR Cipla is well known for is innovations in the field of pharmaceutical but not so for its supply chain and impeccable delivery.This was also the case with the recently launched QVIR which had not been effectively distributed or consumed at the right time. Every year around 5 -7 % of the patients failed their first line treatment because the dose was unavailable and wasn’t there at the stipulated treatment time. For a drug priced at a paltry sum of $ 3 and the life changing benefits of containing four drugs in one single strip, it never served its intended purpose. From our qualitative data collection method we understood that the pain points facing Cipla in the delivery of QVIR were as follows: * Inventory levels are too high and/or misplaced Spending is too high, either indirect or direct categories * Cash-to-cash cycles are too long * Lean manufacturing and quality goals are not being met – potentially accompanied by excess waste generated or scarce resources used Cipla’s Supply Chain Cipla has over 180 manufacturing plant across the world out of which 50 manufacturing plants manufacture QVIR. Cipla also manufac turing some of its own raw material in three of its own factors situated in Mumbai, Himachal Pradesh and Karnataka states of India.For some of the raw materials of QVIR, Cipla also conducts import/export trade with some of its local and international suppliers located in India, Germany, USA, UK, Italy, France, Australian, South Africa and South Korea Chine and Japan. Cipla has its export market in 180 countries of which its main customers are USA, Germany, South Africa, New-Zealand, Australia, China, Sri Lanka, Singapore and Japan. The transportation is carried out internationally via ship and air and domestically either by road or rail. Value Stream Mapping for QVIRThe Top challenges of Cipla’s Supply Chain for QVIR After conducting our initial investigation, assessment and analysis we were able to group the top challenges of Cipla’s supply chain into 3 major components: * Supply Chain Visibility * Increasing Customer Demands * Globalization Supply Chain Visibility Th ere is an inherent lack of willingness to share information and collaborate effectively. Inhibitive organization silos are widespread across Cipla where individuals are too busy to share within the organization and among supply chain networks.This leads to misaligned performance measures, ineffective integration and collaboration not viewed as important. Namita Kelwa, Partner Management director who is also a champion of change within Cipla says, â€Å"When we talk about supply chain visibility, it does not simply mean visibility into your own supply chain and your own shipments. It means visibility among partners, which enables collaborative decision making closer to the customer. This is both a science (managing the technology) and an art (using the information and metrics for competitive advantage). Partial and experimental adoption is widespread in visibility, but extensive adoption is still very low. Increasing Customer Demands Customers are almost always last on the list for synchronizing supply & demand. Cipla as an organization has forgotten to identify that customers continue to have aggressive demands for differentiated products & services, while their own product lifecycles have been shortening. According to Garima Singh, vice president of consumer products, â€Å"We must combine SCM with CRM†¦ get supply chain staff thinking in terms of a commercial customer mindset.Bringing the customer perspective into all facets of SCM will push us to further supply chain excellence† Remaining competitive in developing a new product or service also has the following challenges such as cross function cooperation, product/service innovation and proper allocation of resources. There should be a further integration of customer demands from inception to delivery – the entire Cipla global supply chain network focused on the end customer. Globalization Globalization for many businesses including Cipla is the complexities of interconnectivity.The imp act of global sourcing has led Cipla to experience delivery issues in the form of unreliable commitments especially in the case of the QVIR drugs. It has also resulted in larger than anticipated lead times and quality issues. While looking for lower cost sourcing options, Cipla should pave the way for constantly updated and differentiated business models and distribution strategies. Identifying Risk factors Supplier Risks In the supply chain management of the pharmaceutical industry the selection of supplier should be done very carefully because the raw material can directly affect the finished drug.In CIPLA API Plants the ingredient are manufactured as per Regulatory requirements like USFDA, WHO, MHRA, and TGA and but these API plants are not enough for 50 manufacturing plant so they need external suppliers to provide other ingredients such as Diluants, binding agents, colorant, lubricant and granulating agents. 1. Imports The major risk associated with the import is the availabili ty of the raw material at right time. Some of the delay includes: * Delay in movement of cargo * Custom handling * Delay in processing documents due to system error at Seaport/Airport. Continuous holidays, strike by laborers customs may delay clearances. 2. Inferior Quality of supply Quality is very important in case of any pharmaceutical manufacturing as it directly deals with the life of the people therefore it is governed by many regulations. The inferior Quality of the raw material can increases the risk of waste in the final steps of manufacturing. Some of the adverse effects would be * Breaking and rusting of tables * Short shelf life * Less potency * Side effect to patents * Batch rejection * Market complain Packaging RisksPackaging material for QVIR is one of the important concerns which can not be compromised on the terms of availability and quality, a special packing is needed for the QVIR since it is a four in one drug packing which contain a kit of Tenofovir, Emtricitabi ne, Atazanavir and Ritonavir. If the packaging material is not available in that situation * The raw material shelf life will increase ( as kept in stores) * Productivity will decrease * Unable to fulfill order on time * Holding of batch can increase the reanalysis cost Production Risks 1. Malfunctioning of MachineryIn CIPLA entire process of manufacturing is automated. So efficient working of the machines is essential in that manufacturing process any malfunctioning of machine can lead to increase the production time and cost. 2. Human error Although in the company most of the production process is automated, there is still chance of human error due to negligence of the employee who operates the machines. This can lead to serious problem not only to the company but to the employee himself some of the common human errors are: * Improver gowning * Negligence in handling of material * Improper documentation * Negligence in following SOPs Negligence in maintain personal hygiene * Negli gence in clearing the apparatuses * Negligence during handling chemicals * Negligence during operating machines The human error can led up to some serious problems such as * can cause damage to the life of others * wastage of material * wastage of time * can damage the machine * can lead to batch failure 3. Quality Risks Quality of the QVIR is an important concern for CIPLA pharmaceutical because it directly deals with the life of the customers moreover the industry is highly regulated so it is extremely necessary to produce products with high quality.The inferior quality of drug can cause * Batch rejection * Market complain * Economic lose * Lose of company reputation * As the industry is highly regulated by government law inferior quality can lead to close done of organization Storage Risks Improper storage of the drug special QVIR can lead to serious problems not only to the manufacturer but also to there customers. Some of the common storage risks are * Drug contamination * Drug deterioration * Batch rejection * Market complain * Reduce the self life of drug etc Demand Side Risks 1. Forecasting ErrorsForecasting errors can lead to serious problems related to the long lead times, over production, demand analysis, short life cycle, and order placement in the value chain which lead to bullwhip effect. Forecast error can affect the whole supply chain from the beginning till the end affecting the entire resources in inventory, facilities, transportation, sourcing, pricing and information management so there should be a proper forecast analysis. 2. Transportation Risk The main risk factors involved after the batch is moved out of factor is the transportation risk. The major problem during the transportation process is Tracking the shipment * Delay of the shipment * Product contamination * Stock clearness 3. Information Sharing Risks Information sharing is the foundation on which supply chain processes work. Without information sharing manager cannot indentify th e demand related to the product and the amount to be produced. Information systems will help the manager to know how the inventory is flowing in the supply chain and how the stocks are maintained. Moreover in the production process the flow of information help to minimize the risk and maintain the quality of the product. Risk AnalysisRoot Cause Analysis The root cause analysis can help CIPLA mangers to identify and correct the root causes which may lead to the identified risks Below Fish Bone diagram is used to perform the root cause analysis for Cipla – After conducting the root cause, we were able to establish certain glaring problems in the supply & demand of QVIR such as supplier selection, non-availability of resources, machinery problems, improper management SCM Specific Brainstorming A periodic ‘All Hands’ session has to be conducted with the entire supply chain team of QVIR at Cipla.These sessions could be either fortnightly or monthly basis. During these sessions, members of the team are encouraged to ask several sets of questions related to improvement and transformation of a SMARTER Supply Chain. Some possible questions include: * Do you have real time visibility into the cost & performance of your supply chain both inside and across organizational boundaries? * Are you able to collaborate with your upstream and downstream trading partners on changing supply and demand conditions? Have you exploited rapid ROI opportunities relating to inventory optimization, demand forecasting, network design, and procurement spend? * What are your inventory levels vs. peers, your cash-to cycle time vs. peers? * Is your business able to quickly and directly make changes to supply chain processes and policies based on identified savings opportunities? * Have you balanced your cost reduction initiatives against customer requirements and supply chain risk including those related to sustainability issues? * Would cost reduction quick wins allow inves ting in future necessary SC capabilities?By predicting the risk components while brainstorming and doing the root cause analysis, there are also other risks during production which is more human error and packaging error. As part of the analysis for this assignment, we’ve also assessed the risks during production and how that risk can be controlled Risk Mitigation Supplier Risk Mitigation To overcome all the relative problems with the supplier Cilpa management needs to:- 1. Planning 2. Supplier selection 3. Supplier evaluation 4. Performance measurement 5. Feedback and communication Production Risk MitigationMalfunctioning of the machinery Malfunctioning of machinery in the production process can be overcome by- * Regularly checking and maintaining the working of the machines. The machines should be checked after each batch production. * Special engineers should be hired for the maintenance job with deep knowledge * The checking and maintenance process should be added into th e standard operating process and proper validation process should be conducted for the clearing process for each machine. * There should be a proper training process for the employees who are operating the machines.This will not only prevent the risk in the production process but also help in maintaining the quality of the product. Human error risk The human error can be minimized by providing proper – * training to the employee * maintaining proper standard operating procedures * automating the process where possible * providing proper documentation Packaging Risk Mitigation To minimize the risk in the packing and packaging process Cipla has to move out from the traditional model to more technological side. * Photo scanning system * Ratio frequency identification system and ePedigrees technologyPhoto scanning system is a modern way of minimizing risk in the packaging line by using photo scanning system. Cipla can eliminate the risk on cross labeling, miss printing and over p rinting of the labels this will minimize the risk of batch rejection by the customer in different country Advantage of using Photo Scanner System 1. Minimize the risk cross labeling 2. Minimize the risk of miss print related with date of expire, date of manufacturing and dose to be taken 3. Minimize the waste 4. Safe time 5. Increases the efficacy of the production line.Radio Frequency identification system (RFID) and ePedigees technology is a modern way of thinking in supply chain of Pharmaceutical industry. RFID is a better solution to minimize the risk associated with packaging and delivering, inventory management forecasting, monitoring and collecting data. In this process the RFID tag is attached to the product and than it can be tracked any where in the entire supply chain. The tag transfer electronic information through radio frequency electromagnetic ways that can be read from several meters away.Unlike the traditional bar code system there is no need of aligning the product in front of the reader. There is no chance of data error with this system In this system the electronic documents know as ePedigree are generated. These E pedigee have all the historical information regarding the product movement in the supply chain which makes it easy to monitor the product and remove optical in the supply chain. Advantages of using RFID * Improve Forecasting and Planning * Reduce Out-Of-Stock Conditions * eliminate excess and missing inventory as well as reduce losses and write * Improves Decision-Making Improve Customer Experience. * Reduce Theft * Increase Efficiency of production process * Improves Asset Utilization and Visibility Quality and storage risk mitigation Quality management play most crucial role in the pharmaceutical industry so a systemic monitoring and evaluation of quality in the production process is necessary to reduce the risk associated with the quality of the product This can only be achieved by following strict quality protocols at each st age. The Quality assurance team and the Quality control term should monitor – * The quality of the raw material purchase Storage condition of the raw material and the finished product * The standard operating procedure of the production process * Proper cleaning of the machines as per validation * Quality of the packaging material * SOP for labeling and packaging * Proper storage of the finished good with correct labeling At each step of quality management data should be collected and reports should be generated to identify where the problem is occurring in the supply chain and how to mitigate those problems simultaneously. Demand Side Risk Mitigation Transportation risk mitigation To minimize the risk related to the transportation there should be a proper selection of the transporter as per GMP requirement * There should be a proper procedure to select the logistic supplier * Proper communication * Regular inspection Information flow risk Technology plays an important role t o minimize the risk factor in the information flow. Use of certain ERP tools such as SAP and ORACLE can help CIPLA minimize the risk. Moreover using RFID the electronic documents – epidgees make the flow of information quite easier and quicker.Recommendation The supply chain of the future for Cipla would be Smarter. It would be Instrumented, Interconnected & Intelligent. Flexibility will be the watchword for cost containment, Visibility will become vital, Risk would be managed systematically, and customer input would permeate the supply chain. The smart map of this new supply chain for Cipla would help in the following: * Integrated real-time transactions (ERP) with business intelligence * Multi-partner collaboration platform * Dynamic supply & demand balancing Predictive sense-and-respond event detection & resolution * Probability-based risk management * Supply chain risk analysis & mitigation models * Risk-adjusted inventory optimization * Environmental strategies & policie s with sustainability models for usage impact analysis: Carbon. Energy, Water, Waste * Customer-segmented product lifecycle management * Real-time consumption & replenishment programs * Optimized pipeline inventory * Variable cost structures that fluctuate with market demand * Outsourcing non-differentiating functions Global â€Å"centers of excellence† to optimize capability and delivery * Asset management strategy & global execution Conclusion By employing the risk mitigating factors for this supply chain and leveraging on the data collected, deep supply chain management expertise, methods and analytical tools Cipla can quickly assess current inventory situations for inventory optimization realizing 30-50% inventory reduction, significantly improve demand forecasting accuracy 10-30% and provide direction to reduce spend 5-20%.With the futuristic instrumented, interconnected and intelligent smarter supply chain, smart devices, sensors and actuators can capture real-time data including: shelf-level replenishment, forecasts and orders, pipeline inventory and shipment lifecycle status. Advanced instrumentation will â€Å"sense-and-respond† demand and supply signal notification with thresholds to determine corrective actions from disturbances and there would be more â€Å"self-correcting†, â€Å"self-actuating† transactions.With the new smarter supply chain model and future integration of sustainability principles our desire with this assignment is to have the supply chain emerge as a major business tool that can help control costs, manage risks and make profit in a fully responsible manner. Much of the opportunity to address related energy, water and waste management costs rests on the supply chain.